Effect Of Acetic Acid Supplementation On Pathomorphological And Immunohistochemical Changes In Broiler Chickens Experimentally Infected With Salmonella Enterica Serovar Pullorum
By: Bareera Javed Khan (2009-VA-156)
| Dr. Gulbeena Saleem.
Contributor(s): Prof. Dr. Asim Aslam | Dr. Nisar Ahmed.
Material type: 
BookPublisher: 2016Description: 70p.Subject(s): Department of PathologyDDC classification: 2564-T Dissertation note: The present study was conducted to evaluate the effects of acetic acid in minimizing the severity of pathomorpholgical lesions in broiler chickens experimentally challenged with Salmonella pullorum. The experimental birds were divided into five groups. Group A acted as control, Group B was infected with S. pullorum. Antibiotic and acetic acid was given respectively to the challenged Group C and Group D. Group E was given acetic acid solely. Clinical signs were observed on daily basis. Postmortem findings of birds from each group was recorded on day 1, 3, 5 and 7. Histopathology and immunohistochemistry of the necropsy samples was performed subsequently. The data thus collected was organized using Factorial experiment on computer statistical software Minitab version 16 and analyzed by Two way ANOVA (Analysis of variance).
Hemorrhagic, congested liver with greyish necrotic foci, pericarditis, congested lungs, spleen and unabsorbed yolk was observed in sick birds. Infiltration of inflammatory cells, congestion and necrosis in liver, spleen and heart were histopathologically observed. Acetic acid reduced the severity of gross pathological and histopathological changes. The fecal excretion of S. pullorum significantly reduced with acetic acid.
Results clearly demonstrated that use of acetic acid and antibiotic respectively produced comparable outcome. As the use of antibiotics was banned in European Union and the organism, Salmonella pullorum showed resistance against many antibiotics so the best way to control the disease is by supplementing the acetic acid to birds as it was helpful in minimizing the mortality and severity of gross and histopathological lesions in infected chickens. If diets can be planned to enhance the organic acid production in the caecum, it may be possible to control salmonella species through cost effective means. However further studies need to be conducted in order to analyze the prophylactic and therapeutic effect of organic acids. The use of prebiotics and probiotics along with organic acids on the growth and disease management of broiler chickens.
| Item type | Current location | Collection | Call number | Status | Date due | Barcode | Item holds |
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Thesis
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UVAS Library Thesis Section | Veterinary Science | 2564-T (Browse shelf) | Available | 2564-T |
The present study was conducted to evaluate the effects of acetic acid in minimizing the severity of pathomorpholgical lesions in broiler chickens experimentally challenged with Salmonella pullorum. The experimental birds were divided into five groups. Group A acted as control, Group B was infected with S. pullorum. Antibiotic and acetic acid was given respectively to the challenged Group C and Group D. Group E was given acetic acid solely. Clinical signs were observed on daily basis. Postmortem findings of birds from each group was recorded on day 1, 3, 5 and 7. Histopathology and immunohistochemistry of the necropsy samples was performed subsequently. The data thus collected was organized using Factorial experiment on computer statistical software Minitab version 16 and analyzed by Two way ANOVA (Analysis of variance).
Hemorrhagic, congested liver with greyish necrotic foci, pericarditis, congested lungs, spleen and unabsorbed yolk was observed in sick birds. Infiltration of inflammatory cells, congestion and necrosis in liver, spleen and heart were histopathologically observed. Acetic acid reduced the severity of gross pathological and histopathological changes. The fecal excretion of S. pullorum significantly reduced with acetic acid.
Results clearly demonstrated that use of acetic acid and antibiotic respectively produced comparable outcome. As the use of antibiotics was banned in European Union and the organism, Salmonella pullorum showed resistance against many antibiotics so the best way to control the disease is by supplementing the acetic acid to birds as it was helpful in minimizing the mortality and severity of gross and histopathological lesions in infected chickens. If diets can be planned to enhance the organic acid production in the caecum, it may be possible to control salmonella species through cost effective means. However further studies need to be conducted in order to analyze the prophylactic and therapeutic effect of organic acids. The use of prebiotics and probiotics along with organic acids on the growth and disease management of broiler chickens.
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